Case Study : Le implicazioni culturali/religiose nella terapia con Buprenorfina Long-acting sottocutanea in giovane adulto con disturbo da uso d'oppioidi

relapse with periods of homelessness.Cultural tension intensifi ed during Ramadan, a period associated with autonomous modifi cations of oral medications.The subsequent transition to long-acting injectable buprenorphine provided a culturally acceptable alternative, enhancing adherence and clinical stability.Pharmacogenetic considerations, particularly the higher prevalence of CYP2D6 ultrarapid metabolizers in North African populations, may have contributed to the heightened psychoactive responses and misuse risk.Overall, the case illustrates the necessity of integrating cultural, religious, and pharmacogenetic factors into individualized treatment strategies to improve engagement and long-term outcomes. [Publisher's text]