E-book
Versione Digitale
Scully, M.A. | Stubbs, M. | Thomas, M. | Cataland, S.R.

Fast Facts for Patients : Thrombotic Thrombocytopenic Purpura : Prompt action saves lives

2022 - Karger Publishers

32 p.

  • Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood coagulation system. In most cases, a lack of the ADAMTS13 enzyme leads to an accumulation of ultra-large von Willebrand factor molecules in the plasma which, in turn, initiate the formation of microscopic thromboses in small blood vessels. TTP is a medical emergency. Timely diagnosis and urgent and effective management are vital - mortality in those untreated is in the region of 90%. The understanding of TTP pathogenesis has increased markedly in recent decades. It is now known that TTP is acquired (immunemediated) or congenital, and that the most common type - the acquired form - predominantly affects women in their 40s. It is also clear that the prompt delivery of plasma exchange saves lives. 'Fast Facts: Thrombotic Thrombocytopenic Purpura' sets out, in a clear and accessible format, the steps to suspecting, diagnosing and treating this potentially devastating disease. These steps are complemented by clear descriptions of the dis
  • ease mechanism and epidemiology. Differential diagnosis, which is of the utmost importance for this disease, is explored in detail. Table of Contents: - Disease overview - Clinical presentation - Differential diagnosis - Laboratory findings and diagnosis - Management [Publisher's text].
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