Torrossa Online Digital Bookstore 0

Your store for digital research texts

Book, Study of intracellular signaling pathways in chronic myeloproliferative neoplasms, Martinelli, Serena, Firenze University Press
Study of intracellular signaling pathways in chronic myeloproliferative neoplasms
2017 - Firenze University Press
ID: 4335087
ISBN: 9788864535654
  • Information

    75 p. : ill.

    • A gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). Enhanced activation of other downstream pathways including the PI3K/mTOR pathway has been documented as well. In this study we evaluated the effects of JAK1/2 inhibitors, alone and in combination with mTOR, with a dual mTOR/PI3K inhibitor and with a pan PI3K inhibitor in in-vitro and in-vivo MPN models. Our findings of strong synergy between the JAK2 inhibitors and mTOR/PI3K inhibitor suggested that we might be able to administer these drugs at lower concentrations than when the drugs are used individually. This provides a framework for combination trials using compounds in patients with myeloproliferative neoplasms.
    • Serena Martinelliobtained the PhD title in Biomedical Science at Florence University in 2016. She is co-author in several articles and she is listed as the leading author in one of them. Her technical skills and competences are cellular biology, molecular biology and mouse models. [Publisher's text].
    • Includes bibliographical references.