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Kalgutkar, Amit S. | Dalvie, Deepak | Mannhold, Raimund | Smith, Dennis A. | Obach, R. Scott

Reactive Drug Metabolites

2012 - Wiley-VCH

402 p.

power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training. [Publisher's Text]

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